Trying to do anything in our WP Admin site is horrendously slow since the 4.5.2 update. Switching from post to dashboard used to take 1-5 seconds now takes 20 to 30. I've disabled all plugins, and still have the problem. Using Genesis with Foodie Pro theme (Just noticed that Foodie Pro is version 2.0.5, but i see in 2.1.8 is the latest - i'll try to update and see what happens).
Site users do not seem to have this issue. It is only the wp-admin site that seems to be really slow.
I saw this article (https://wordpress.org/support/topic/upgrade-to-wp-452-blocks-all-admin-access?replies=2) so I think some others are having the same issue.